Coronary atherosclerosis is the leading cause of ischaemic heart disease [31], but ecILK cKO epicardial coronary arteries showed no sign of remodelling. In contrast, small arterioles (10–60 μm) showed evident wall remodelling (Fig. 4A), peaking at three weeks after endothelial ILK deletion (Fig. 4B and C). Here, ILK is linked to coronary atherosclerosis.