HLAs encode the cell surface proteins that are part of the major histocompatibility complex (MHC) and are involved in immune response and suppression.62 Other genes, including USP17L26, USP17L27 and GAGE2A_2, are involved in cellular response to viral infection.63 Of note, two genes GOLGA6L4 and LOC102724117-2 have been reported to be associated with waist circumference.64 The accelerated pattern in CN1 allele indicates potential selection signals for the population carrying these alleles. This evidence concerns the gene USP17L26 and viral infectious disease.