Interestingly, the pathogenic variations of PRKAR1A were observed in both atrial myxoma and ventricular myxoma, but the pathogenic variations of KIF1C were only observed in LAM, suggesting that variations in KIF1C may be pathogenic and that KIF1C is a new pathogenic candidate gene for CM, especially for LAM. Here, PRKAR1A is linked to lymphangioleiomyomatosis.