The expression of KIF1C was significantly decreased in the myxoma tissues of LAM patients with KIF1C variations (c.772 T > G, c.899 A > T, and c.352 A > T), as well as PRKAR1A. Besides, the expressions of KIF1C and PRKAR1A were both decreased in myxoma tissues of CM patients with PRKAR1A variations (c.289 C > T, c.*847 A > G, c.738Tdel, and c.770-2 A > G), which suggested that KIF1C and PRKAR1A may have upstream and downstream interactions. The gene discussed is KIF1C; the disease is myxoma.