PKA activates the ERK pathway to upregulate the expression of SNAI1, SNAI1 binds to the E-box consensus sequence in the CDH1 promoter, inhibits the expression of CDH1, promotes epithelial-mesenchymal transition (EMT), and eventually increases the proliferation and migration of lung adenocarcinoma cells27. Here, SNAI1 is linked to lung adenocarcinoma.