Other than c.772 T > G and c.899 A > T, four variations of KIF1C were identified by Sanger sequencing in LAM patients (Fig. 2a, b, and Supplementary Fig. 2): c.352 A > T in exon 5, which causes the encoded amino acid isoleucine to be converted to phenylalanine; c.2895 C > T in exon 23, where the encoded proline remains unchanged; c.3049 G > A in exon 23, which causes the encoded amino acid alanine to be converted to threonine; c.*442_*443dup in the 3’UTR. The gene discussed is KIF1C; the disease is lymphangioleiomyomatosis.