MAPT and Alzheimer disease: Also, exposure of zebrafish to ZnCl2 higher than 1 ppm produced Alzheimer’s disease (AD)-like syndrome including suppression of ACh, decrease locomotor behavior, and impairment in short-term memory due to activation on AChE. Moreover, ZnCl2 induces amyloid-β and phosphorylated Tau protein levels in brains52.