Phosphoglycerolipid metabolism (M1.1-M1.3 and S1) and thiamine metabolism pathways (M2 and S2) were enriched in HCC, while amino acid metabolism (M3.1-M3.3 and S3, and M4 and S4), nucleotide metabolism (M5 and S5), and glycolysis pathways (M6 and S6) were enriched in iCCA (Supplementary Table S10). Here, PRRT2 is linked to hepatocellular carcinoma.