CRP and obesity due to melanocortin 4 receptor deficiency: We found that the regions with altered co-accessibility, marginal effects on CRP and other obesity-related traits, and GxE signals affecting CRP were enriched in regions of the genome that exhibit features of a more developmentally primed cellular state (cluster 1), rather than in the regions enriched for super-enhancers and highly interacting gene promoters (cluster 5).