Transcriptome data from the TCGA database showed that the RNA level of LRPPRC was positively correlated with that of CDK6 (n = 515, Rho = 0.327, P < 0.0001) and E2F1 (n = 515, Rho = 0.383, P < 0.0001) in lung adenocarcinoma; and the positive correlation tendency was widespread in different tumors (Fig. 4l, m and Supplementary Fig. S7i). The gene discussed is E2F1; the disease is lung adenocarcinoma.