HAVCR2 and colonic neoplasm: To verify that rabeprazole induces an antitumor immune response, we analyzed the immune cell subsets of colon cancer transplanted tumors by fluorescence-activated cell sorting (FACS) and found a significant increase in CD3+ CD8+ T cells and a significant decrease in CD3+ CD8+ PD1+ T cells, CD3+ CD8+ TIM3+ T cells and CD3+ CD8+ PD1+ TIM3+ T cells (Fig. 7d).