Finally, we analysed the prognostic significance of MRPS12 and NDUFS6 expression pattern: results in the global population (503 patients) showed that metastasis-free survival (MFS) of patients with high MRPS12 or NDUFS6 expressing tumours (10-year MFS of 41 and 46%, respectively) was shorter than that of patients with low MRPS12 or NDFUS6 expressing tumours (10-year MFS of 66% for both genes;) (P = 0.001 for MRPS12 and p = 0.0016 for NDFUS6, Fig. 7B). The gene discussed is MRPS12; the disease is neoplasm.