Gliogenic shift seen in DS brains and mouse models76 and iPSC neurospheres77 can also be caused by the constitutional loss of LMNB1. 78Neuronal migration defects (seen in neurons from DS hiPSCs)79 are mimicked by Lmnb1-null mice,80 that also show reduced neuronal numbers in the cortex. The gene discussed is LMNB1; the disease is Dravet syndrome.