From within the CRO1 duplicated region, DYRK1A was selected as a candidate gene based on its multiple reported dose-sensitive effects on brain abnormalities in DS, including neurodevelopment, retina development and Alzheimer’s type neurodegeneration,51, 52, 53, 54 as well as its interaction with proteins involved in DNA-repair55, 56, 57 and cellular quiescence.58 Here, DYRK1A is linked to Dravet syndrome.