LMNB1 and Dravet syndrome: The list of DS neurodevelopmental phenotypes that could be counter-acted by the early therapeutic restoration of Lamin B1 levels can best be estimated by comparing the pathological phenotypes between individuals with DS, LMNB1+/− patients, and Lmnb1−/− mice, and it includes: impaired neuronal migration, reduced neuron numbers at specific brain locations, gliogenic shift during brain development, reductions in gyral folding, dendritic spines and synaptic puncta.