Using a combination of immunohistochemistry, immunofluorescence and immunoblotting we show that Lamin B1 levels were significantly lower in foetal DS skin fibroblasts (mesodermal origin), foetal DS brain (ectodermal origin), and foetal and infant DS liver tissue (endodermal origin) (Fig. 7). The gene discussed is LMNB1; the disease is Dravet syndrome.