Examination of published literature, driven by the Lamin B1-laminopathy-hypothesis for DS, reveals that indeed, multiple, major DS neurodevelopmental abnormalities have been mirrored in LMNB1 knockdown models: reduced dendritic spine density,72 Tau redistribution in dendrites (neurons from hiPSCs),73 decrease in synaptic puncta74 (neurons from hiPSCs), are all seen in Lmnb1-K.O. Here, MAPT is linked to laminopathy.