HEXB and Alzheimer disease: Furthermore, progranulin (GRN), pyrin domain containing 1 (PYDC1), B-cell linker protein (BLNK), spleen tyrosine kinase (SYK), solute carrier family 2 member 5 (SLC2A5), and hexosaminidase subunit beta (HEXB) have also been identified as risk genes for the progression and development of AD [99].