NLRP3 and Cognitive impairment: In another study, Ma et al. showed that the knockdown of Su(var)3-9, enhancer-of-zeste, and trithorax domain-containing protein 7 improved cognitive impairment and ameliorated cell pyroptosis, which is associated with the inhibited release of inflammatory cytokines, and suppresses the activation of the NLRP3 inflammasome in the hippocampus in isoflurane-induced aged mice [46].