To determine if PCa angiogenesis can be induced by overexpression of N-MYC and TEM8, a tubule formation assay was conducted using human umbilical vein endothelial cells, and immuno-histochemistry analysis revealed that N-MYC and TEM8 expression levels were positively correlated in PCa tissue [355]. This evidence concerns the gene ANTXR1 and posterior cortical atrophy.