In a nuclear factor-erythroid 2 (NF-E2) -related factor 2 (NRF2) knockout Apcmin/+ mouse model, increased c-MYC expression in intestinal tissue is accompanied by high proliferating cell nuclear antigen (PNCA) levels, which promote intestinal carcinogenesis and adenomas, due to intestinal crypt cell proliferation [136]. Here, NFE2L2 is linked to adenoma.