PGP and cancer: Experiments to verify the relationships among MYC, SNHG12, and P-gp showed that SNHG12 and MYC overexpression partially increase levels of P-gp and Ki67 (a gene that promotes cellular proliferation) in transfected YTS cells and promote cancer cell proliferation by desensitizing cells to CDDP; whereas P-gp expression and CDDP sensitivity were markedly reduced by knocking down SNHG12 in SNK-6 cells [368, 371].