MYC and cancer: Further, PCAT-1 knockdown CRC cells exhibited dramatically reduced c-MYC production, correlated with reduced c-MYC-dependent invasiveness and drug resistance; however, overexpression of MYC in PCAT-1 knockout cells partially restored cell invasion and drug resistance, demonstrating that PCAT-1 is a regulator of the MYC gene and that c-MYC protein is fundamental in triggering PCAT-induced cancer cell aggression [362].