CCL2 and cancer: Inflammation contributes to cancer and in vivo MYC activation stimulates mast cells and neutrophils, which rapidly migrate to the tumor site, inducing various cytokines and growth factors, such as vascular endothelial growth factor (VEGF) and chemokine (C-C motif) ligand 2 (CCL2), that facilitate angiogenesis and promote tumor metastasis [115, 116].