No association between higher MYC protein levels and increased CD40 transcription was observed in patients with diffuse large B cell lymphoma; however, MYC overexpression decreases levels of the co-stimulatory genes, TNF receptor superfamily member 4 (TNFRSF4) and forkhead box P3 (FoxP3), in regulatory T cells (Tregs) [125]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.