RIT1 and cardiac hypertrophy: Recent murine models of RIT1 NS, independently developed by our group and others, present features that recapitulate clinical manifestations, including a shortened stature, craniofacial dysmorphism, and cardiac hypertrophy (13, 14), providing an avenue for the evaluation of therapies against hypertrophic cardiomyopathy (HCM) and other cardiac defects closely associated with RIT1 NS in a preclinical setting.