Overlap included postsynaptic neurotransmission in C9-ALS-FTSD and sALS, glial migration in C9-ALS-FTSD and SOD1-ALS, and chemokine-mediated signalling, and T cell, B cell and natural killer cell processes in sALS and SOD1-ALS (Supplementary material). Here, SOD1 is linked to amyotrophic lateral sclerosis.