CNN2 and amyotrophic lateral sclerosis: Interestingly, differential expression analysis revealed significant dysregulation of immune response genes (i.e. complement and microglial genes) in cognitively impaired cases (C9-ALS-FTSD, sALS) (Supplementary Fig. 2C and D) while only one significantly dysregulated gene, CNN2, was detected between unimpaired cases (C9-ALS-FTSD, sALS) and controls.