Despite these differences, heat map cluster analysis of C9-ALS-FTSD, sALS and SOD1-ALS cases using the filtered NPS gene list revealed two distinct NPS subgroups, present across the included cohorts, again delineated by the expression of two gene clusters related to immune response or axonal transport and synaptic processes (Fig. 5C and Supplementary Fig. 2A and B for full panel and GO). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.