Neuron development, projection and differentiation gene sets were downregulated in C9-ALS-FTSD cases relative to controls, as well as gene sets for synaptic structure, plasticity and transmission, cell projection organization and cytochrome c release; blood microparticle, platelet degranulation, endopeptidase inhibitor activity and inflammatory response gene sets were upregulated (Fig. 1C). The gene discussed is CYCS; the disease is amyotrophic lateral sclerosis.