In addition, the USP28 expression of GBM tissue was negatively related to most signal pathways, including xenobiotic metabolism, TNFA-signaling-via-NFKB, P53 pathway, oxidative phosphorylation, KRAS signaling, inflammatory-response, IL6-JAK-STAT3-signaling, complement, coagulation, and apoptosis. This evidence concerns the gene TNF and glioblastoma.