Several studies indicate that USP28 is closely related to the progression and prognosis of liver carcinogenesis [37], GBM [38], and sarcoma [39], so we performed Kaplan–Meier curves analysis of ACC, LGG, KICH, and SARC, which indicated that a higher USP28 was associated with poor OS (Figure 9C) outcomes. Here, USP28 is linked to adrenal cortex carcinoma.