Specifically, the OS analysis results showed that USP28 was a risk factor for poor prognosis of ACC, BLCA, BRCA, DLBC, HNSC, KICH, KIRP, LGG, LIHC, LUAD, PAAD, PCPG, SARC, SKCM, and UVM while a protective factor for patients with KIRC, OV, and READ. This evidence concerns the gene USP28 and adrenal cortex carcinoma.