Ubiquitin-specific peptidase 28 (USP28) is a deubiquitinase (DUB) enzyme belonging to the USP family, which was discovered to be closely related to cell-cycle progression, DNA repair, apoptosis, proliferation, and tumorigenesis [4–6], which suggested USP28 might be a promising target for cancer therapy. The gene discussed is USP28; the disease is cancer.