IFNGR2 and Huntington disease: Notably, RelA binding was detected in the promoter region of IFNGR2 in HD conditions (Supplementary Fig. S6F), which is consistent with the RNA-seq data in which we detected the upregulation of IFNGR2 in HD conditions (Fig. 3H) and suggests that IFNGR2 is a direct transcriptional target of RelA.