Nonetheless, RelA silencing resulted in the downregulation of IFNγ target genes with key roles in antigen presentation that we identified as direct RelA transcriptional targets in ER+ breast cancer cells, such as ICAM1 (66), HLA-A, TAP1, B2M, and CXCL10 (Fig. 5I and J). Here, IFNG is linked to breast carcinoma.