In summary, the decision between survival and necroptotic cell death during pancreatitis appears to be a function of mtROS levels, which are at least in part governed by a reciprocal regulation between p53 and the SRX-PRX3 antioxidant system, with p53 promoting an mtROS buildup by causing the inactivation of PRX3 by hyperoxidation through the downregulation of SRX, and the SRX-PRX3 system restraining p53 mitochondrial accumulation by decreasing mtROS levels (Rius-Pérez et al., 2022). Here, SRXN1 is linked to pancreatitis.