HMGB1 and acute pancreatitis: Interestingly, the circadian transcription factor BMAL1 (also known as aryl hydrocarbon receptor nuclear translocator-like) regulates the expression of key ferroptotic inhibitory genes, such as SLC7A11 and GPX4, and pancreatic-specific Bmal1-deficient mice exhibited enhanced pancreatic ferroptosis in acute pancreatitis with increased mortality, tissue injury, neutrophil infiltration, and HMGB1 release (Liu et al., 2020).