During pancreatitis in mice lacking SRX, necroptosis occurred much faster, and could be prevented by the mitochondrial antioxidant MitoTEMPO, therefore indicating the critical importance of mtROS in necroptosis activation, and hence the role of PRX3 and SRX in mitigating mtROS levels (Rius-Pérez et al., 2022). The gene discussed is SRXN1; the disease is pancreatitis.