GPX4 and acute pancreatitis: Oxidative stress and glutathione depletion are involved in the onset of acute pancreatitis (Moreno et al., 2014), and pancreatic-specific Gpx4 deficiency exacerbates cerulein-induced pancreatitis in mice via a trypsin-dependent mechanism (Dai et al., 2020; Liu et al., 2022b).