Another necroptotic DAMP, cfDNA, was, however, detected in the plasma of mice with acute pancreatitis in parallel with the presence of necroptosis in the pancreas, indicating that cfDNA levels but not HMGB1 levels may serve as a marker of necroptosis (Rius-Pérez et al., 2022). The gene discussed is HMGB1; the disease is acute pancreatitis.