Five genes were upregulated in AT/RT-SHH recurrences: RGL2, NPIPA5, TMEM259, KAT2A, and CA4. While the biological function of these genes seems to be diverse, some of these (such as RGL2) have been ascribed pro-metastatic functions in other tumor entities [6, 27, 33]. This evidence concerns the gene TMEM259 and neoplasm.