TP53 and endothelial dysfunction: On EPA-E treatment, testicular caspase-3, p53 as well as number of apoptotic nuclei were significantly attenuated suggesting potential anti-apoptotic properties of EPA-E which is consistent with a previous study that reported antiapoptotic effect of eicosapentaenoic acid in palmitic acid-induced endothelial dysfunction (Lee et al. 2014).