It is noteworthy that the most common c.470C>T (p.I157T) variant scored intermediate in both kinase assays that is consistent with KAP1 assay performed previously (17) and with its low (clinically unimportant) but statistically significant association with breast cancer risk (OR∼1.5) documented in heterozygous p.I157T carriers (24). Here, TRIM28 is linked to breast carcinoma.