Given that EFNA1‐related pathways were widely observed in the pathogenesis of multiple cancers, and with a novel epigenetic perspective provided by our study that EFNA1 could possibly increase the risk of cancers through DNA methylation modification, the further mechanisms of the interaction between EFNA1 and cancers need to be investigated, and therapies targeting EFNA1‐related pathways are well worth developing. Here, EFNA1 is linked to cancer.