Seizure recurrence (number of seizure events, score 2–5) was increased by the maternal Mthfr+/− genotype and decreased by the offspring Mthfr+/− genotype (F1,58 = 5.47, p = 0.023, F1,58 = 4.96, p = 0.03, respectively). This evidence concerns the gene MTHFR and Seizure.