BHLHE40 and encephalomyelitis: Based on this analysis, there are several ways in which TCR signaling-dependent GATA3 expression via Crebbp, Fos, Myc, Cebpa, and/or STAT6 might help induce Egr2. Egr2, or possibly GATA3 itself, may help to directly induce Bhlhe40, and Bhlhe40 in turn regulates Csf2 expression resulting in GM-CSF-dependent encephalomyelitis in EAE.