The top five most activated Kyoto Encyclopedia of Genes and Genomes (KEGG) terms involving ITGB1 were insulin signaling pathway, ERBB signaling pathway, regulation of actin cytoskeleton, chronic myeloid leukemia, and neurotrophin signaling pathway (Figure 8D). This evidence concerns the gene ITGB1 and chronic myelogenous leukemia, BCR-ABL1 positive.