The top five most activated Kyoto Encyclopedia of Genes and Genomes (KEGG) terms involving ITGB1 were insulin signaling pathway, ERBB signaling pathway, regulation of actin cytoskeleton, chronic myeloid leukemia, and neurotrophin signaling pathway (Figure 8D). The gene discussed is EGFR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.