• Hemopoiesis: Reduce incidence of myelosuppression• DAMP: ↑Production by tumor cells• Lymphocytes:↑Increase CD3+ and CD4+ T cells; ↑CD4+/CD8+ ratio↑Th1 differentiation in cancer↓Th1,↓Treg, ↑Th17 in ITP• NK cells: ↑Increase NK cells; ↑NK activity• DC cells:↑Promote maturation↑DC-induced T cell proliferation & Th1 differentiation• Macrophages:↓Proliferation and infiltration in tumor↑Promote M1 polarization; ↑Promote phagocytosis↓Suppress motility; ↓MΦ-induced angiogenesis. This evidence concerns the gene CD4 and neoplasm.