IGHE and parasitic infectious disease: For example, IgM is the prototype of antibody that responds early to initial attacks and primarily distributes intravascularly; IgG is the main type of antibody in blood and tissues that emerges later after isotype switching; IgA as the secretory type of antibody is involved in mucosa-associated immunity, and IgE is commonly implicated in allergic reaction and parasitic diseases (38, 81).