GLI1 and cancer: However, other studies have reported that AIM2 acts as a tumor suppressor gene in many cancers including colon cancer and endometrial cancer (6, 14),inhibiting cancer proliferation, invasion and migration through various mechanisms, including suppressing glioma-associated oncogene-1 (GLi1) (15), inactivating PI3K/AKT/mTOR signaling (16), Moreover, the trigger mechanisms of the AIM2 inflammasome remain unknown.