Even though a stronger increase in cellular response after a second instance of COVID-19 exposure was observed in healthy controls, the aCD20-MS cohort maintained higher mean spike-specific cytokine+-secreting T-cell numbers before (geometric mean aCD20-MS vs HC fold increase: IFNγ+ = 3.9X, P< 0.001; IL-2+ = 3.6X, P< 0.001; IFNγ+/IL-2+ = 3.5X, P< 0.001) and after re-exposure (3.2X, P = 0.002; 1.4X, P = 0.05; 2.2X, P = 0.004). This evidence concerns the gene IL2 and COVID-19.