Interestingly, and contrary to the observed spike-specific T-cell response, CEFX-specific response was lower in aCD20-MS patients compared to HC, reaching significant difference for IL-2+ (P = 0.006) and IFNγ+/IL-2+ (P = 0.004) (Figure S6, 1st exposure). Here, IL2 is linked to myeloid sarcoma.