Regnase-1 is expressed less in PH subtype, while mice lacking Regnase-1 in alveolar macrophages develop severe PH, and transcriptomic analysis has shown that IL-6 is a potential target for Regnase-1 in alveolar macrophages of PAH patients, demonstrating that Regnase-1 might be another mediator of IL-6 in monocytes/macrophages in PH (Figure 1) (97). Here, ZC3H12A is linked to pulmonary arterial hypertension.