In pancreatic cancer, IL-6 induces the expression of Jagged-1/2 through Jak/STAT signaling, which enhances the expression of IL-6 mRNA in fibroblast cell lines through the NF-κB pathway to form a positive feedback loop and stimulates the production of platelets to form a hypercoagulable state (142). The gene discussed is IL6; the disease is familial pancreatic carcinoma.