ASF1A and chronic myelogenous leukemia, BCR-ABL1 positive: Mechanistically, ASF1A was proposed to play an active role in initiating Notch signaling and upregulating H3K56 acetylation, which in turn resulted in CML acceleration and blast crisis.68 Roles of H3.2 and CENP-A in regulating hematopoiesis or driving hematological malignancy have not yet been described in literature.