A prominent example of this is the polycomb-associated gene ASXL1, which is found to be recurrently mutated in various hematological malignancies including clonal hematopoiesis, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and chronic myelomonocytic leukemia (CMML).8–10ASXL1 mutations are associated with inferior overall survival.11,12 Furthermore, in some cases, mutations in chromatin regulators can co-occur. The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.