MAPT and Alzheimer disease: The pathognomonic feature of AD is the deposition of amyloid (Aβ) peptides in the extracellular matrix (amyloid plaques), the presence of neurofibrillary tangles (hyperphosphorylated tau protein) in the cortex, amygdala, and hippocampus, neuronal loss, neuroinflammation, and oxidative stress [8,11].