ENO1 and neoplasm: α-Enolase (ENO1) is one of the most important enzymes in the glycolytic pathway, and at the same it is a multifunctional oncoprotein contributing to hit seven “hallmarks of cancer” (Huang et al., 2022) Moonlighting of ENO1 is involved in deregulating of cellular energetic, sustaining of tumor proliferation, inhibiting of cancer cell apoptosis, as well as evading of growth suppressors and immune surveillance.