Furthermore, in different works, it was shown that nuclear PKM2 interacts with hypoxia-inducible factor-1α (HIF-1α), thus increasing the expression of its target genes (such as GLUT1 and LDHA) and providing metabolic reprogramming of tumour cells (Luo et al., 2011; Wang et al., 2014). Here, LDHA is linked to neoplasm.