Besides, ENO1 is expressed on the surface of several cell types, where it acts as a plasminogen receptor, concentrating plasmin proteolytic activity on the cell surface (Perconti et al., 2017), and thus ENO1 is involved in extracellular matrix (ECM) remodeling, cancer invasion, and metastasis by inducing angiogenesis (Huang et al., 2022). The gene discussed is PLG; the disease is cancer.