HK1 and neoplasm: Overexpression of almost all glycolytic enzymes in cancer cells contribute to most of the hallmarks of cancer (Hanahan, 2022), such as sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, enabling replicative immortality, tumour-promoting inflammation, activating invasion and metastasis, inducing or accessing vasculature, resisting cell death, deregulating cellular metabolism (Heiden et al., 2009; Bu et al., 2018; Ciscato et al., 2021; Huang et al., 2022).