An immunohistochemical study of melanoma by Zhuang et al. (2010) showed that the expression of LDH-A strongly correlates with the expression of the antiapoptotic proteins Mcl-1 and Bcl-XL, while the elimination of LDH-A increases the cleavage of poly-(ADP-ribose) polymerase (PARP) and reduces the expression of the X-linked inhibitor of apoptosis protein (XIAP), Bcl-2 and Bcl-XL, which led to a decrease in the oncogenicity of the pancreatic cell line BxPC-3 (Rong et al., 2013). Here, BCL2L1 is linked to melanoma.