It is possible that lncRNA Erbb4-IR may mediate Ang II-induced cardiac disease by reducing cardiac Smad7. This is consistent with our previous finding that Erbb4-IR acts as an integrated effector molecular to promote renal fibrosis by targeting Smad7 by directly binding to the 3′ UTR of the Smad7 genomic sequence.21 This evidence concerns the gene AGT and renal fibrosis.