,32,33 Importantly, our recent study also found that the Erbb4-IR-miR-29b axis is a key mechanism of type 2 diabetic nephropathy because Erbb4-IR can bind the 3′ UTR of the miR-29b genomic sequence to suppress miR-29b expression at the transcriptional level.22 The gene discussed is INSR; the disease is type 2 diabetes nephropathy.