It was found that Cur-B reduced the expression of Jagged-1 by 0.83 ± 0.03, 0.76 ± 0.07, 0.50 ± 0.04, and 0.26 ± 0.05 folds, whereas this reduction for Hes-1 was found to be 0.89 ± 0.03, 0.73 ± 0.03, 0.49 ± 0.05, and 0.21 ± 0.04 folds, as compared to the vehicle or control in PCa cells (Figure 8). The gene discussed is JAG1; the disease is posterior cortical atrophy.