Strong increases toward the tumor center were observed for CXCR3+CXCR6+ cells (population 13) and CCR5+CXCR3+CXCR6+ CD8+ TRM cells (population 9), concurrent with a decrease in CCR5 single-positive (population 12) as well as CCR2+CCR5+CXCR6+ (population 3) CD8+ TRM cells (Figure 2c). Here, CXCR3 is linked to neoplasm.