Altogether, although chemokine receptor co-expression patterns differed between trNK cells and CD8+ TRM cells, increased CXCR6 expression on both cell types toward the tumor center indicate that CXCR6 constitutes a key-receptor for mediating the accumulation of trNK cells and CD8+ TRM cells in lung tumors. This evidence concerns the gene CXCR6 and neoplasm.