In addition, Ottaviani et al. demonstrated the PBM in a mouse model of melanoma with 660–970 nm NIR laser delayed tumor growth and increased the recruitment of T cells and DCs.54 Similarly, Petrellis et al. showed that PBM on the tumor site of Walker sarcoma model rats using 660 nm laser increased expression of IL-1β, COX-2, and iNOS but decreased IL-6, IL-10, and TNF-α, suggesting the immunomodulatory effects of PBM.55 These results indicate that the main mechanisms of PBM could involve stimulation of the immune system. This evidence concerns the gene TNF and neoplasm.