TAMs skewed toward an M2-like phenotype not only secrete cytokines such as IL10 and TGFβ that suppresses the activity of intratumoral T cells, but also promote the formation of a dense extracellular matrix around the tumor, which act as a physical barrier preventing effector T cells and therapeutic compounds from penetrating the tumor (34). This evidence concerns the gene TGFB1 and neoplasm.