IHC-based analysis revealed significant hyperactivation of phosphorylated levels of AKT (pAKT; Ser473) and P70S6K (pP70S6K; T421/S424) within the pancreatic tumor ductal compartment of both KPC and PKT as compared with pancreata of non–tumor-bearing Ptf1aCre/+ control mice (Fig. 1B). Here, RPS6KB1 is linked to neoplasm.