Other than TFE3 positivity and primary metastatic disease, the other variables that correlated with worse OS in the univariable analysis were receiving two lines of therapy (HR: 14.4, 95% CI: 2.3–90.0, P = 0.004), malignant PEComa histology (HR: 8.1, 95% CI: 1.0–65.3, P = 0.05). The gene discussed is TFE3; the disease is metastatic neoplasm.