Chondroitin sulfate is upregulated in the ECM of more than 90% of HGSOC and linked to poor prognosisAcquisition of mesothelial–mesenchymal phenotype by cancer cells, characterized by expression of CALB2 and PDPN, regulates adhesion to ECM and tumor progression and is correlated to poor outcome. This evidence concerns the gene PDPN and neoplasm.