High expression of PI3K or AKT is correlated to shorter OS in ovarian cancerUBE2S is a potential oncogene that, through stimulation of PI3K/AKT/mTOR pathway, enhances proliferation and migration of ovarian cancer. Its high expression is a poor prognostic factorInhibition of PI3K in wild-type PI3KCA ovarian cancer induces BRCA downregulation and with PARP inhibitors shows synergistic effect against ovarian cancer. The gene discussed is MTOR; the disease is ovarian cancer.