Mechanosensory signals produced by ascites and tumor expansion regulate EMT and interaction with EMC, as well as enhance angiogenesis, stemness, and chemoresistanceShear stress stimulates stemness by increase of CD44, CD117, and OCT4 activityECM stiffness upregulates expression of stemness CD133 markerCompression changes activity of the Wnt/β-catenin pathway and regulates EMTExpression of PAX8 links migratory and adhesive properties of Fallopian tube epithelium, STIC, and HGSOC cells. Inhibition of PAX8 reduces ability of cancer cells to migrate and adhere to fibronectin and collagen. The gene discussed is FN1; the disease is cancer.