Graphene oxide–silver nanocomposite combined with salinomycin showed high toxicity against ALDH+CD133+ OCSCsCOX/5-LOX inhibitor that reversed stem-like properties in spheroids and augmented paclitaxel activity resulting in prolongation of mice survivalOvarian cancer II-IV FIGO. Metformin in combination with standard chemotherapy in neoadjuvant and adjuvant setting. Median PFS of 18 months, and median OS of 58 months. Tumors treated with metformin had a 2.4-fold decrease in ALDH+CD133+ CSCs and showed increased sensitivity to cisplatin. Here, PROM1 is linked to cancer.