UBR5-mediated immunosuppressive TAM infiltration augments tumor growth and metastases and, through activation of p53/β-catenin/CCL2 pathway, stimulates spheroid formationCAPG gene expression is correlated with infiltration of tumors by Tregs, M2 TAMs, and exhausted T cells contributing to immunosuppression in HGSOCTAMs exert pro-tumor and immunosuppressive effects through secretion of IL10,TGFβ, VEGF, and expression of PD-1 and consumption of arginine to inhibit T-cell efficacy. The gene discussed is CCL2; the disease is neoplasm.