High numbers of Tregs in tumor immune infiltrates are considered a sign of poor prognosisT CD8+/Tregs and CD4+/Tregs ratio are a good predictors of patient survivalAbundance of Tregs and increased VEGF in ascites are observed in patients with poor prognosisHowever, the prognostic value of Tregs depends on the tumor type and stage, and, in HGSOC tumors, lower Th17/Tregs ratio was correlated with better survival. The gene discussed is VEGFA; the disease is neoplasm.