Salinomycin is the mono carboxylic polyether antibiotic inhibiting ABC-transporter system and promoting OCSC apoptosis.Encapsulated salinomycin in the form of salinomycin-loaded high-density lipoprotein showed effective cellular uptake and reduced the EMT, stemness, and angiogenesis mediated by OCSCsCombined treatment reduced stemness and spheroid forming capability and enhanced apoptosis of ascitic OCSCsCombination of drugs reduced a significant number of CD44+CD117+ OCSCs and inhibited tumor growth. Here, ABCG2 is linked to neoplasm.