The signature of genes associated with regulation of hypoxia and immune response allow to divide patients with ovarian cancer into high- or low-risk groupsHigher ALOX5AP, ANXA1, PLK3, and SREBF1 mRNA levels are significantly associated with shorter OS, whereas LAG3 and IGFBP2 lower mRNA levels with better prognosis, respectivelyExpression of seven hypoxia-related genes—UQCRFS1, KRAS, KLF4, HOXA5, GMPR, ISG20, and SNRPD1—divides ovarian cancer into two populations with different prognosisHypoxia-related miR-23a-3p is overexpressed in HGSOC showing chemoresistance and shorter PFS. The gene discussed is SREBF1; the disease is ovarian cancer.