Inhibition of JAK2/STAT3 signaling results in decrease of stemness and reduced tumor growthInhibition of JAK/STAT pathway in HGSOC cells and CAFs has anti-tumor activityOCT4 accelerates tumor growth and enhances chemoresistance through activation of JAK/STAT pathway in OCSCs represented by “side population”LIF and IL-6 secreted by MSCs promote OCSC function by STAT3 signaling. Here, JAK2 is linked to neoplasm.