The TLC, neutrophil count, NLR, PLR, and NMR were all significantly higher than the RBC parameters (Hb, HCT, RBC, MCH, MCHC, and RDW), lymphopenia, eosinopenia, basopenia, monocytopenia, and LMR in the second-wave patients. The gene discussed is GSTM1; the disease is Decreased total monocyte count.