Unexpectedly, there were no differences in serum GPIHBP1 levels in type 2 diabetes patients with and without hypertriglyceridemia, whereas serum GPIHBP1 levels were significantly higher in patients with type 2 diabetes with diabetic retinopathy, DN and microvascular complications than in those without these complications. Here, GPIHBP1 is linked to hypertriglyceridemia.