The important discovery was that the chow‐fed Gpihbp1 knockout mice (Gpihbp1−/−) showed severe hypertriglyceridemia with plasma TG levels ranging from 2,500 to 3,500 mg/dL14, 15, 16 and markedly reduced LPL in the post‐heparin plasma, suggesting that GPIHBP1 plays a critical role in LPL‐mediated TG‐rich lipoprotein processing. The gene discussed is LPL; the disease is hypertriglyceridemia.