Among the several lifestyle factors linked to COPD risk, the maximum number of studies are on the interaction between smoking and COPD-related genetic variants, such as rs10193706 near testis expressed 41 (TEX41), contributing to COPD risk in UK Biobank data and rs1051730, rs16969968, and rs1799895 polymorphisms of glutathione S-transferase Mu-1 (GSTM1) interact with smoking, contributing to COPD risk in Mongolians [14,18]. Here, TEX41 is linked to chronic obstructive pulmonary disease.