IL1B and Alzheimer disease: Moreover, the potential of Lupeol in AlCl3-induced neurotoxicity in Wistar rats was observed, where the elevated levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and degenerative changes in the hippocampal brain region in AD were inhibited by treatment with Lupeol (25 and 50 mg/kg, p.o.)[100].