Among the well-known modes of action of auraptene as an anti-tumor agent, it suppressed the expression of MMP-2, MMP-7, and MMP-9 proteins in colon cancer cells and colonic mucosa from colitis mice [17] and also repressed MMP-2 and -9 activity to inhibit the migration and invasion of cervical and ovarian cancer cells [18]. Here, MMP2 is linked to malignant colon neoplasm.