Studies have shown that excessive alcohol consumption can lead to myocardial cell dysfunction (abnormal calcium homeostasis), increased norepinephrine levels, and decreased myocardial contractility, leading to alcoholic cardiomyopathy [60,61,62]; moderate alcohol consumption has been shown to have a certain preventive effect on the prevention of heart failure, which may be related to the increase in high-density lipoprotein cholesterol, insulin sensitivity, plasma adiponectin level, inhibition of inflammation, and improvement of endothelial function. Here, INS is linked to heart failure.