IL6 and obesity due to melanocortin 4 receptor deficiency: In fact, following an intake of pomegranate juice or extract, several clinical trials have shown a decrease in IL-6 blood levels in patients suffering from type 2 diabetes [46], obesity [47], non-alcoholic fatty liver disease [48], undergoing hemodialysis [49], or in athletes in which strenuous exercise may induce systemic inflammation [50].