IFNG and Hypertension: This is further augmented by the increased activation of NADPH oxidase that is mediated by increased salt entry via the ENaC leading to the formation of isolevuglandin (IsoLG)-protein adducts, adaptive immune activation, and secretion of inflammatory cytokines such as IL-17A, TNF-α, and interferon-gamma (IFN-γ) that contributes to the development of hypertension and exacerbates the already existing CVDs [110,113,114,115] (see Figure 3).