The activating molecules of becn1 regulatory autophagy protein 1 (AMBRA1), Bcl2L13, FUN14 domain-containing protein 1 (FUNDC1), and NFKB-1 mitochondrial ubiquitin ligase activator (MUL1)2 in neuronal cells in AD are reduced, and the levels of lipid-modified microtubule-associated protein light chain 3 (LC3B-II) and beclin-1 are lower, with both autophagosomes and autosome numbers being reduced in AD neurons [52,54]. This evidence concerns the gene BECN1 and Alzheimer disease.