PPARGC1A and Alzheimer disease: Katouri et al. further demonstrated the neuroprotective effects of PGC-1α by transferring PGC-1a to the cortical and hippocampal CA1 regions of AD mice using a lentiviral vector, which demonstrated that the upregulation of PGC-1α can improve mitochondrial dynamics, as well as spatial memory and cognitive function, and it can prevent neuronal loss [87].