A genetic-risk score of ABCG5/8 variants predicting 1 mmol/L increase in non-HDL-C was associated with a two-fold increase in CAD risk (OR: 2.01, 95% CI: 1.75, 2.31) compared with a 54% increase in CAD risk (OR: 1.54, 95% CI: 1.49, 1.59) associated with a score of other variants in genes expect for ABCG5/8 (such as apolipoprotein B, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase -reductase, proprotein convertase subtilisin/kexin type 9, and LDL receptor) predicting the same increase in non-HDL-C [76]. The gene discussed is LDLR; the disease is coronary artery disorder.