A recent study examined the effects of ABCG5/8 and NPC1L1 variants on nonhigh-density lipoprotein cholesterol (non-HDL-C) (n = 610,532) and circulating phytosterol levels (n = 3039), as well as CAD risk in individuals of European origin from Iceland, Denmark, and the UK Biobank (105,490 cases and 844,025 controls) [76]. Here, NPC1L1 is linked to coronary artery disorder.