There are several recognized mechanisms for the development of acne: excess sebum production, hyperproliferation of the bacterium Cutibacterium acnes, hyperkeratinization of the pilosebaceous follicles, and inflammatory mechanisms, in which, insulin-like growth factor 1 (IGF-1) appears to be a key factor in potentiating pathogenesis mechanisms that lead to acne progression and severity by sebum overproduction, as well as sebocyte and keratinocyte proliferation. Here, IGF1 is linked to acne.